Sau Shun Wong, Luen Chow Chan, Chi Ping Lai, Wing Yuk Ip, Lok Hang Chau
Biodegradable metals have attracted interest for implant applications because of the potential to eliminate secondary surgeries. Magnesium-based (Mg-based) alloys are potential candidates. The purpose of this study was to evaluate the in vitro and in vivo degradation performances of two custom-made magnesium-based alloys and to determine whether they are sustainable for further investigation. The performances of Magnesium-Zinc-Manganese (Mg-Zn-Mn) alloys at 5% and 1% zinc levels were compared using a mechanical test, hydrogen evolution test, cell viability (MTT) test, and a short term mice subcutaneous implantation. The results showed that the corrosion resistance of the Mg was improved by alloying. While Mg-5Zn-1Mn was more corrodible compared with Mg-1Zn-1Mn, neither of the alloys presented any adverse effects preliminarily and both were suitable for long-term testing for biomedical applications.