Bacterial cellulose (BC), a biopolymer synthesized by various bacterial species, has emerged as a promising material for biomedical applications due to its unique properties, including high purity, biocompatibility, mechanical strength, and structural similarity to the extracellular matrix. This review explores the advancements in BC research over the last decade, focusing on its applications in tissue engineering, wound healing, and drug delivery systems. While BC offers numerous benefits, challenges such as large-scale production, structural modification, however regulatory approval hinder its broader clinical use. Recent studies have introduced innovative solutions, such as using agro-industrial waste to lower production costs and combining BC with other materials to enhance its bioactivity. As research progresses, BC has the potential to revolutionize the field of biomedicine, offering sustainable, versatile, and effective solutions for a wide range of medical applications.